기타학회
| Pharmacokinetics of Amikacin in Korean Premature Infants | ||
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학회명 ; 05년도 춘계학술대회 (대한약학회) 일시/장소 ; 4. 18 / 교육문화회관
Methods : Demographic and pharmacokinetic data were collected for 64 preterm infants (27 females and 37 males) treated with amikacin in Asan Medical Center during the periods of February 2003 through February 2005. The medication was infused over 30 min and 166 serum levels (83 peak/trough pairs) were taken at steady state. The correlations between pharmacokinetic parameters and patient characteristics such as gestational age (GA), postnatal age (PNA), postconceptional age (PCA), and birth weight were evaluated by simple correlation analysis.
Results : The mean GA was 31.3 ± 3.7 weeks, the mean PCA was 35.7 ± 3.9 weeks, the mean PNA was 30.6 ± 23.2 days, and the mean birth weight was 1.66 ± 0.86 (SD) kg. The mean ± SD of half-life, volume of distribution, elimination rate constant, and clearance were 5.64 ± 2.52 hours, 0.54 ± 0.12 L/kg, 0.14 ± 0.05 hr -1, and 0.08 ± 0.03 L/kg/hr, respectively. The significant correlations were found between amikacin clearance and the PCA (r = 0.533, p<0.01) and the PNA (r=0.414, p<0.01). There were no significant correlations between amikacin clearance and the GA and birth weight. The mean half-life of 3 PCA subgroups were 9.5 ± 2.4 hr in PCA£29 weeks, 6.3 ± 2.6 hr in PCA 30 to 34 weeks, and 4.7 ± 1.7 hr in PCA≥35 weeks. No significant difference in volume of distribution was found between 3 subgroups.
Conclusions : This pharmacokinetic study of amikacin may be useful in determining the initial dosing regimen for Korean premature infants.
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