기타학회
| Analysis of adverse drug reactions in children | ||
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학회명 : American Academy of Allergy Asthma & Immunology Song, Ph.D.,Jinho Yu, M.D., Ph.D., Soo-Jong Hong, M.D., Ph.D. Childhood Asthma Atopy Center, Research Center for Standardization of Allergic Diseases, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine
Rationale The incidence of adverse drug reactions(ADRs) is increasing. However, the studies about the prevalence of ADRs in children are rare compared to reports in adult. In order to investigate the causative drugs and clinical features of ADRs in children, we performed a study in a tertiary university hospital of Korea.
Method We prospectively collected ADR data by a computerized spontaneous reporting system at our university hospital. ADR data of children under the age 18 collected from January 2005 to May 2011 were analyzed.
Results 1924 ADR cases were reported in 1086 male(56%) and 838 female(44%), and mean age was 9.3±5.9 years(0-18 years). Antibiotics(n=769, 45%) were the most common causative drugs, followed by analgesics(n=144, 9%) such as tramadol and opiate, non-steroidal anti-inflammatory agents(NSAIDs) and acetylsalicylic acid(n=124, 7%), radiocontrast media(n=77, 5%) and sedatives(n=70, 4%). The most common clinical features were skin manifestations(n=961, 52%) such as urticaria, pruritus, skin rash and angioedema. Gastrointestinal symptoms(n=402, 22%) were the second clinical features, followed by respiratory symptoms(n=157, 9%) including mainly dyspnea. Among antibiotics, penicillin/ß-lactamase inhibitors(n=80, 16%), third-generation cephalosporins(n=78, 15%) and glycopeptides(n=66, 13%) were the most frequently reported causative drugs.
conclusion Antibiotics were reported most common causative drug of ADRs in children and the clinical features were mainly skin reactions. Close monitoring system may be useful to detect ADRs early in children.
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